Salivary duct carcinoma
| Salivary duct carcinoma | |
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Low magnification micrograph of a salivary duct carcinoma with characteristic comedonecrosis (left of image) adjacent to normal parotid gland (right of image). H&E stain.
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| Classification and external resources | |
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| Patient UK | Salivary duct carcinoma |
Salivary duct carcinoma, abbreviated SDC, is a rare type of aggressive cancer that arises from the salivary glands.[1] It is predominantly seen in men and, generally, has a poor prognosis.[2] Other high grade carcinomas can mimic SDC. About 40-60% of SDC arise in pleomorphic adenomas. Most, if not all, SDCs express androgen receptor by immunohistochemistry. [3] Therapeutically relevant genetic alterations include ERBB2/Her2 amplification, PIK3CA and/or HRAS mutations.[4][5]
Symptoms
The typical presentation is a rapidly growing mass with associated pain.[2] This may be seen in association with neck lymph node swelling (cervical lymphadenopathy), due to metastases, and facial nerve paralysis.
Diagnosis
SDC are diagnosed by examination of tissue, e.g. a biopsy.
Their histologic appearance is similar to ductal breast carcinoma.
See also
Additional images
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Salivary duct carcinoma - very low mag.jpg
Very low mag.
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Salivary duct carcinoma - intermed mag.jpg
Intermed. mag.
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Salivary duct carcinoma - very high mag.jpg
Very high mag.
References
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