Sinomenine

Sinomenine

Systematic (IUPAC) name
(+)-4-Hydroxy-3,7-dimethoxy-17-methylmorphin-7-en-6-one
Identifiers
CAS Number	115-53-7 Y
ATC code	none
PubChem	CID: 5459308
ChemSpider	10179905
ChEMBL	CHEMBL248095 N
Synonyms	Cocculine
Chemical data
Formula	C19H23NO4
Molecular mass	329.390 g/mol
SMILES CN1CC[C@@]23CC(=O)C(=C[C@@H]2[C@@H]1CC4=C3C(=C(C=C4)OC)O)OC
NY (what is this?)  (verify)

Sinomenine or cocculine is an alkaloid found in the root of the climbing plant Sinomenium acutum which is native to Japan and China. It is traditionally used in herbal medicine in these countries, as a treatment for rheumatism and arthritis. However, its analgesic action against other kinds of pain is limited. Sinomenine is a morphinan derivative, related to opioids such as levorphanol and the non-opioid cough suppressant dextromethorphan. Its anti-rheumatic effects are thought to be primarily mediated via release of histamine, but other effects such as inhibition of prostaglandin, leukotriene and nitric oxide synthesis may also be involved.

See also

• Hasubanan