Small nucleolar RNA SNORA65
| Small nucleolar RNA SNORA65 | |
|---|---|
| 220px | |
| Predicted secondary structure and sequence conservation of SNORA65 | |
| Identifiers | |
| Symbol | SNORA65 |
| Alt. Symbols | U65 |
| Rfam | RF00302 |
| Other data | |
| RNA type | Gene; snRNA; snoRNA; H/ACA-box |
| Domain(s) | Eukaryota |
| GO | 0006396 0005730 |
| SO | 0000594 |
SNORA65 (also known as U65) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a 'guide RNA'.
U65 was originally cloned from HeLa cells [1] and belongs to the H/ACA box class of snoRNAs as it has the predicted hairpin-hinge-hairpin-tail structure and has the conserved H/ACA-box motifs.[2] snoRNA U65 is predicted to guide the pseudouridylation of residues U4373 and U4427 of 28S ribosomal RNA (rRNA).[3] Pseudouridylation is the isomerisation of the nucleoside uridine to pseudouridine(Ψ). U65 is related to the snoRNA MBII-351 identified in mouse.[4]
References
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- ↑ Entry for U65 at snoRNABase
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
External links
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