Small nucleolar RNA SNORA73
From Infogalactic: the planetary knowledge core
Small nucleolar RNA SNORA73 family | |
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Predicted secondary structure and sequence conservation of SNORA73 | |
Identifiers | |
Symbol | SNORA73 |
Alt. Symbols | U17 |
Rfam | RF00045 |
Other data | |
RNA type | Gene; snRNA; snoRNA; HACA-box |
Domain(s) | Eukaryota |
GO | 0006396 0005730 |
SO | 0000594 |
In molecular biology, the small nucleolar RNA SNORA73 (also called U17/E1 RNA) belongs to the H/ACA class of small nucleolar RNAs (snoRNAs). Vertebrate U17 is intron-encoded and ranges in length from 200-230 nucleotides, longer than most snoRNAs. It is one of the most abundant snoRNAs in human cells and is essential for the cleavage of pre-rRNA within the 5' external transcribed spacer (ETS).[1] This cleavage leads to the formation of 18S rRNA. Regions of the U17 RNA are complementary to rRNA and act as guides for RNA/RNA interactions, although these regions do not seem to be well conserved between organisms.[2]
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