Succinylation

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Succinylation is a posttranslational modification where a succinyl group (-CO-CH2-CH2-CO-) is added to a lysine residue of a protein molecule. This modification is found in many proteins, including histones.[1] The potential role of succinylation is under investigation, but as addition of succinyl group changes lysine's charge from +1 to −1 and introduces a relatively large structural moiety (bigger than during acetylation or methylation), it is expected to lead to more significant changes in protein structure and function.[2]

By analogy to acetylation, it has been suggested that succinyl-CoA is the cofactor of enzyme-mediated lysine succinylation.

References

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External links

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