AMPA

For other uses, see AMPA (disambiguation).

AMPA

Names
IUPAC name 2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic acid
Identifiers
CAS Number	74341-63-2 N
ChEMBL	ChEMBL276815 N
ChemSpider	1184 Y
DrugBank	DB02057 Y
IUPHAR/BPS	4131
Jmol 3D model	Interactive image
KEGG	C11033 Y
MeSH	AMPA
PubChem	1221
InChI InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12) Y Key: UUDAMDVQRQNNHZ-UHFFFAOYSA-N Y InChI=1/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12) Key: UUDAMDVQRQNNHZ-UHFFFAOYAT
SMILES O=C1/C(=C(\ON1)C)CC(N)C(=O)O
Properties
Chemical formula	C7H10N2O4
Molar mass	186.17 g·mol−1
Vapor pressure	{{{value}}}
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YN ?)
Infobox references

AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) is a compound that is a specific agonist for the AMPA receptor, where it mimics the effects of the neurotransmitter glutamate.

There are several types of glutamatergic ion channels in the central nervous system including AMPA, kainic acid and N-methyl-D-aspartic acid (NMDA) channels. In the synapse, these receptors serve very different purposes. AMPA can be used experimentally to distinguish the activity of one receptor from the other in order to understand their differing functions. AMPA generates fast excitatory postsynaptic potentials (EPSP). AMPA activates AMPA receptors that are non-selective cationic channels allowing the passage of Na⁺ and K⁺ and therefore have an equilibrium potential near 0 mV.

See also

• Ampakine