Biphenylindanone A

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Biphenylindanone A
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Systematic (IUPAC) name
3’-(((2-cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydro- 1H-inden-5-yl)oxy)methyl)biphenyl-4-carboxylic acid
Identifiers
ATC code none
PubChem CID: 9868580
IUPHAR/BPS 3954
ChemSpider 8044271 YesY
ChEMBL CHEMBL593013 YesY
Chemical data
Formula C30H30O4
Molecular mass 454.556 g/mol
  • c3cc(C(O)=O)ccc3-c(ccc4)cc4COc(c1C)cc(c(C2=O)c1C)CC2C5CCCC5
  • InChI=1S/C30H30O4/c1-18-19(2)28-25(15-26(29(28)31)22-7-3-4-8-22)16-27(18)34-17-20-6-5-9-24(14-20)21-10-12-23(13-11-21)30(32)33/h5-6,9-14,16,22,26H,3-4,7-8,15,17H2,1-2H3,(H,32,33) YesY
  • Key:KMKBEESNZAPKMP-UHFFFAOYSA-N YesY
  (verify)

Biphenylindanone A (BINA, LS-193,571) is a research agent which acts as a potent and selective positive allosteric modulator for the group II metabotropic glutamate receptor subtype mGluR2.

In animal studies it showed anxiolytic and antipsychotic effects,[1] and blocked the effects produced by the hallucinogenic drug DOB. BINA and other selective mGluR2 positive modulators have therefore been suggested as a novel class of drugs for the treatment of schizophrenia which may have superior properties to traditional antipsychotic drugs.[2]

BINA decreases cocaine self-administration in rats, with no effect on food self-administration, and is in regard to this discrimination superior to the mGluR2/3 agonist LY-379,268[3]

References

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