Azacyclonol

Azacyclonol

Systematic (IUPAC) name
Diphenyl(piperidin-4-yl)methanol
Clinical data
Legal status	℞ (Prescription only)
Routes of administration	Oral
Identifiers
CAS Number	115-46-8 N Template:CAS (HCl)
ATC code	none
PubChem	CID: 15723
ChemSpider	14952 Y
UNII	2MMR990PEM Y
ChEMBL	CHEMBL127508 Y
Synonyms	MER-17, MDL-4,829
Chemical data
Formula	C18H21NO
Molecular mass	267.37 g/mol
SMILES OC(c1ccccc1)(c2ccccc2)C3CCNCC3
InChI InChI=1S/C18H21NO/c20-18(15-7-3-1-4-8-15,16-9-5-2-6-10-16)17-11-13-19-14-12-17/h1-10,17,19-20H,11-14H2 Y Key:ZMISODWVFHHWNR-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Azacyclonol (trade names Ataractan, Calmeran, Frenoton, Frenquel, Psychosan), also known as γ-pipradol, is a drug which is a so-called ataractive, or agent which diminishes hallucinations in psychotic individuals. It has also been called a tranquilizer and antipsychotic, though these definitions are not accurate as it does not actually possess such properties. Despite being a positional isomer of pipradrol, it is not a psychostimulant, and instead has mild depressant effects.

The drug was introduced in Europe in the mid-1950s for the treatment of schizophrenia likely because it was found to attenuate the subjective psychedelic effects of LSD and mescaline in humans. However, due to poor and mixed clinical effectiveness it never gained widespread acceptance and was eventually discontinued.

The antihistamine agent terfenadine produces azacyclonol as an active major metabolite.

It is made by the organometallic addition of 4-bromopyridine to benzophenone, followed by catalytic hydrogenation of the pyridine heteroaromatic ring system to the corresponding piperidine.

See also

• Pipradrol
• Terfenadine
• Fexofenadine