Thiethylperazine

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Thiethylperazine
Thiethylperazine.svg
Systematic (IUPAC) name
2-(ethylthio)-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
Pharmacokinetic data
Protein binding 60%
Identifiers
CAS Number 1420-55-9 YesY
ATC code R06AD03 (WHO)
PubChem CID: 5440
IUPHAR/BPS 7306
DrugBank DB00372 YesY
ChemSpider 5245 YesY
UNII 8ETK1WAF6R YesY
KEGG D02354 YesY
ChEBI CHEBI:9544 YesY
ChEMBL CHEMBL1378 YesY
Chemical data
Formula C22H29N3S2
Molecular mass 399.618 g/mol
  • S(c2cc1N(c3c(Sc1cc2)cccc3)CCCN4CCN(C)CC4)CC
  • InChI=1S/C22H29N3S2/c1-3-26-18-9-10-22-20(17-18)25(19-7-4-5-8-21(19)27-22)12-6-11-24-15-13-23(2)14-16-24/h4-5,7-10,17H,3,6,11-16H2,1-2H3 YesY
  • Key:XCTYLCDETUVOIP-UHFFFAOYSA-N YesY
  (verify)

Thiethylperazine (Torecan) is an antiemetic of the phenothiazine class. Though it was never licensed or used as an antipsychotic, it may have such effects.

Thiethylperazine activates the transport protein ABCC1 that clears beta-amyloid from brains of mice.[1]

References

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