Clotiapine

Clotiapine

Systematic (IUPAC) name
8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzothiazepine
Clinical data
Trade names	Etumina, Etumine, Entumin, Etomine, Entumine
AHFS/Drugs.com	International Drug Names
Legal status	℞ (Prescription only)
Routes of administration	Oral, Intravenous and Intramuscular
Identifiers
CAS Number	2058-52-8 N
ATC code	N05AH06 (WHO)
PubChem	CID: 16351
ChemSpider	15510 Y
UNII	Z05HCY0X1T Y
KEGG	D01597 Y
ChEMBL	CHEMBL304902 Y
Chemical data
Formula	C18H18ClN3S
Molecular mass	343.87 g/mol
SMILES Clc2ccc1Sc4c(/N=C(\c1c2)N3CCN(C)CC3)cccc4
InChI InChI=1S/C18H18ClN3S/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18/h2-7,12H,8-11H2,1H3 Y Key:KAAZGXDPUNNEFN-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Clotiapine (Entumine) is an atypical antipsychotic of the dibenzothiazepine chemical class. It was first introduced in a few European countries (namely, Belgium, Italy, Spain and Switzerland), Argentina, Taiwan and Israel in 1970.

Some sources regard clotiapine as a typical antipsychotic rather than atypical due to its high incidence of extrapyramidal side effects compared to the atypicals like clozapine and quetiapine, to which it is structurally related. Despite its profile of a relatively high incidence of extrapyramidal side effects it has demonstrated efficacy in treatment-resistant schizophrenic patients according to a number of psychiatrists with clinical experience with it, some weak clinical evidence supports this view too.

See also

• Loxapine Amoxapine
• Quetiapine
• Zotepine