Canrenone

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Canrenone (INN, USAN) (brand names Contaren, Luvion, Phanurane, Spiroletan), also known as aldadiene,[1] is a steroidal antimineralocorticoid and weak antiandrogen and progestogen[2][3] of the spirolactone group related to spironolactone which is or has been used as a diuretic in Europe, including in Italy and Belgium.[4][5][6]

Carenone is a major active metabolite of spironolactone, canrenoic acid, and potassium canrenoate, and is believed to be partially or largely responsible for their effects.[7]

Canrenone is more potent as an antimineralocorticoid relative to spironolactone, but is considerably less potent and effective as an antiandrogen.[8][9] Similarly to spironolactone, canrenone inhibits steroidogenic enzymes such as 11β-hydroxylase, cholesterol side-chain cleavage enzyme, 17α-hydroxylase, and 21-hydroxylase, but once again, is comparatively less potent in doing so.[10]

Canrenone has been found to be effective in the treatment of hirsutism in women.[11]

See also

References

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