DUSP15

Dual specificity phosphatase 15
250px PDB rendering based on 1yz4.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1YZ4
Identifiers
Symbols	DUSP15 ; VHY
External IDs	MGI: 1934928 HomoloGene: 33586 GeneCards: DUSP15 Gene
EC number	3.1.3.16, 3.1.3.48
Gene ontology Molecular function • protein tyrosine phosphatase activity • protein binding • protein tyrosine/serine/threonine phosphatase activity Cellular component • cytoplasm • plasma membrane Biological process • protein dephosphorylation • transforming growth factor beta receptor signaling pathway • peptidyl-tyrosine dephosphorylation • regulation of cell proliferation • positive regulation of JNK cascade Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	128853	252864
Ensembl	ENSG00000149599	ENSMUSG00000042662
UniProt	Q9H1R2	Q8R4V2
RefSeq (mRNA)	NM_001012644	NM_001159376
RefSeq (protein)	NP_001012662	NP_001152848
Location (UCSC)	Chr 20: 31.85 – 31.87 Mb	Chr 2: 152.94 – 152.95 Mb
PubMed search	[1]	[2]

Dual specificity protein phosphatase 15 is an enzyme that in humans is encoded by the DUSP15 gene.

The protein encoded by this gene belongs to the non-receptor class of the protein-tyrosine phosphatase family. The encoded protein has both protein-tyrosine phophatase activity and serine/threonine-specific phosphatase activity, and therefore is known as a dual specificity phosphatase. Three transcript variants, encoding two different isoforms have been found for this gene.