PTPN21

Protein tyrosine phosphatase, non-receptor type 21
Identifiers
Symbols	PTPN21 ; PTPD1; PTPRL10
External IDs	OMIM: 603271 MGI: 1344406 HomoloGene: 5110 ChEMBL: 4060 GeneCards: PTPN21 Gene
EC number	3.1.3.48
Gene ontology Molecular function • protein tyrosine phosphatase activity • protein binding Cellular component • cytoplasm • cytoskeleton Biological process • protein dephosphorylation • peptidyl-tyrosine dephosphorylation Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE PTPN21 1320 at tn.png
File:PBB GE PTPN21 40524 at tn.png
File:PBB GE PTPN21 205438 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11099	24000
Ensembl	ENSG00000070778	ENSMUSG00000021009
UniProt	Q16825	E9PZ70
RefSeq (mRNA)	NM_007039	NM_001146199
RefSeq (protein)	NP_008970	NP_001139671
Location (UCSC)	Chr 14: 88.47 – 88.55 Mb	Chr 12: 98.68 – 98.74 Mb
PubMed search	[1]	[2]

Tyrosine-protein phosphatase non-receptor type 21 is an enzyme that in humans is encoded by the PTPN21 gene.

Function

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis.

Interactions

PTPN21 has been shown to interact with BMX and KIF1C.