PF-4455242

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PF-4455242
PF-4455242.svg
Systematic (IUPAC) name
2-Methyl-N-{[2’-(1-pyrrolidinylsulfonyl)-4-biphenylyl]methyl}-1-propanamine
Clinical data
Routes of
administration		 Oral
Identifiers
CAS Number 1202647-54-8
ATC code None
PubChem CID: 44599828
ChemSpider 26610764
Chemical data
Formula C21H28N2O2S
Molecular mass 372.524 g/mol
  • CC(C)CNCC1=CC=C(C=C1)C2=CC=CC=C2S(=O)(=O)N3CCCC3
  • InChI=1S/C21H28N2O2S/c1-17(2)15-22-16-18-9-11-19(12-10-18)20-7-3-4-8-21(20)26(24,25)23-13-5-6-14-23/h3-4,7-12,17,22H,5-6,13-16H2,1-2H3
  • Key:OWVIKBRKPCTDEP-UHFFFAOYSA-N

PF-4455242 is a selective, short-acting (non-"inactivating") antagonist of the κ-opioid receptor.[1][2] Discovered by Pfizer in 2009, it was pursued in a phase I clinical trial for the treatment of bipolar disorder,[3] and was also investigated as a treatment for depression and substance abuse.[4] However, development was stopped in September 2010 due to toxicology findings in animals that had been exposed to the drug for three months.[3]

See also

References

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