ATF6
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Activating transcription factor 6, also known as ATF6, is a protein that, in humans, is encoded by the ATF6 gene[1][2][3] and is involved in the unfolded protein response.
Function
ATF6 is an endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor that activates the transcription of ER molecules.[4] Accumulation of misfolded proteins in the Endoplasmic Reticulum results in the proteolytic cleavage of ATF6. The cytosolic portion of ATF6 will move to the nucleus and act as a transcription factor to cause the transcription of ER chaperones.
See also
Interactions
ATF6 has been shown to interact with YY1[5] and Serum response factor.[2]
References
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External links
- ATF6 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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