ING1

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Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Inhibitor of growth protein 1 is a protein that in humans is encoded by the ING1 gene.[1][2][3]

Function

This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.[3]

Location on Chromosome 13

ING1 is located near the following genes on Chromosome 13

  • CARKD Carbohydrate Kinase Domain-Containing Protein (Unknown Function)
  • COL4A2: A2 Subunit of type IV collagen
  • RAB20: Potential regulator of Connexin 43 trafficking.
  • CARS2: Mitochondrial Cystienyl-tRNA Synthetase 2

Interactions

ING1 has been shown to interact with:

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References

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Further reading

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External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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