MYB (gene)
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Myb proto-oncogene protein also known as transcriptional activator Myb is a protein that in humans is encoded by the MYB gene.[1][2]
Function
Myb proto-oncogene protein is a member of the MYB (myeloblastosis) family of transcription factors. The protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression. This protein plays an essential role in the regulation of hematopoiesis and may play a role in tumorigenesis, including the regulation of miR-155 in B-cells.[3]
Plant orthologs
MYB factors represent a family of proteins that include the conserved MYB DNA-binding domain. Plants contain a MYB-protein subfamily that is characterised by the R2R3-type MYB domain.[4]
In maize, phlobaphenes are synthesized in the flavonoids synthetic pathway[5] from polymerisation of flavan-4-ols[6][7] which encodes an R2R3 myb-like transcriptional activator[8] of the A1 gene encoding for the dihydroflavonol 4-reductase (reducing dihydroflavonols into flavan-4-ols)[9] while another gene (Suppressor of Pericarp Pigmentation 1 or SPP1) acts as a suppressor.[10] The maize P gene encodes a Myb homolog that recognizes the sequence CCT/AACC, in sharp contrast with the C/TAACGG bound by vertebrate Myb proteins.[11]
In sorghum, the corresponding yellow seed 1 gene (y1)[12] also encodes a R2R3 type of Myb domain protein that regulates the expression of chalcone synthase, chalcone isomerase and dihydroflavonol reductase genes required for the biosynthesis of 3-deoxyflavonoids.[13]
Ruby is a MYB transcriptional activator of genes that produce anthocyanin in citrus fruits. In most citrus varieties Ruby is non-functional, but in blood oranges it upregulates anthocyanin production to produce the characteristic red color of the fruit. [14]
References
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External links
- MYB protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Drosophila Myb oncogene-like - The Interactive Fly
- Arabidospsis thaliana MYB family at Database of Arabidopsis Transcription Factors (DATF)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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- ↑ Structural And Transcriptional Analysis Of The Complex P1-wr Cluster In Maize. Wolfgang Goettel, Joachim Messing. Plant & Animal Genomes XVI Conference
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- ↑ Lua error in package.lua at line 80: module 'strict' not found. INIST:13772300
- ↑ The myb-homologous P gene controls phlobaphene pigmentation in maize floral organs by directly activating a flavonoid biosynthetic gene subset. Erich Grotewold, Bruce J. Drummond, Ben Bowen and Thomas Peterson, Cell, 11 February 199, Volume 76, Issue 3, pages 543-554, doi:10.1016/0092-8674(94)90117-1 PMID 8313474
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