Adatanserin

Adatanserin

Systematic (IUPAC) name
N-[2-(4-pyrimidin-2-ylpiperazin-1-yl)ethyl]adamantane-1-carboxamide
Identifiers
CAS Number	127266-56-2 N
ATC code	none
PubChem	CID: 130918
ChemSpider	115774 Y
UNII	W5U6WQM26H Y
ChEMBL	CHEMBL2107510 N
Chemical data
Formula	C21H31N5O
Molecular mass	369.50 g/mol
SMILES O=C(NCCN2CCN(c1ncccn1)CC2)C35CC4CC(CC(C3)C4)C5
InChI InChI=1S/C21H31N5O/c27-19(21-13-16-10-17(14-21)12-18(11-16)15-21)22-4-5-25-6-8-26(9-7-25)20-23-2-1-3-24-20/h1-3,16-18H,4-15H2,(H,22,27) Y Key:HPFLVTSWRFCPCV-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Adatanserin (WY-50,324, SEB-324) is a mixed 5-HT_1A receptor partial agonist and 5-HT_2A and 5-HT_2C receptor antagonist. It was under development by Wyeth as an antidepressant but was ultimately not pursued.

Adantaserin has been shown to be neuroprotective against ischemia-induced glutamatergic excitotoxicity, an effect which appears to be mediated by blockade of the 5-HT_2A receptor.

See also

• Flibanserin