Buclizine

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Buclizine
Buclizine.svg
Systematic (IUPAC) name
(RS)-1-[(4-chlorophenyl)- phenyl-methyl]-4- [(4-tert-butylphenyl) methyl] piperazine
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
Identifiers
CAS Number 82-95-1 YesY
ATC code R06AE01 (WHO)
PubChem CID: 6729
IUPHAR/BPS 7134
DrugBank DB00354 YesY
ChemSpider 6473 YesY
UNII 0C94V6X681 YesY
ChEBI CHEBI:3205 YesY
ChEMBL CHEMBL1201271 N
Chemical data
Formula C28H33ClN2
Molecular mass 433.028 g/mol
  • Clc1ccc(cc1)C(c2ccccc2)N3CCN(CC3)Cc4ccc(cc4)C(C)(C)C
  • InChI=1S/C28H33ClN2/c1-28(2,3)25-13-9-22(10-14-25)21-30-17-19-31(20-18-30)27(23-7-5-4-6-8-23)24-11-15-26(29)16-12-24/h4-16,27H,17-21H2,1-3H3 YesY
  • Key:MOYGZHXDRJNJEP-UHFFFAOYSA-N YesY
 NYesY (what is this?)  (verify)

Buclizine is an antihistamine and anticholinergic of the piperazine derivative family. It is considered to be an antiemetic, similar to meclizine.[1]

In the United Kingdom, buclizine is one of three drugs contained in Migraleve tablets, marketed by McNeil Healthcare at migraine sufferers.[2]

References

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  1. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
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