Bromazine

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Not to be confused with Promazine.
Bromazine
File:Bromazine.svg
Systematic (IUPAC) name
2-[(4-bromophenyl)-phenylmethoxy]-N,N-dimethylethanamine
Clinical data
MedlinePlus a682065
Routes of
administration		 Oral
Pharmacokinetic data
Bioavailability High
Protein binding 96%
Metabolism Mostly hepatic (CYP-mediated), also renal
Biological half-life 1 to 4 hours
Identifiers
CAS Number 1808-12-4 YesY Template:CAS
ATC code R06AA01 (WHO)
PubChem CID: 2444
IUPHAR/BPS 7132
DrugBank DB01237 YesY
ChemSpider 2350 YesY
UNII 202J683U97 YesY
ChEBI CHEBI:59177 YesY
ChEMBL CHEMBL1201245 N
Chemical data
Formula C17H20BrNO
Molecular mass 334.251 g/mol
  • Brc1ccc(cc1)C(OCCN(C)C)c2ccccc2
  • InChI=1S/C17H20BrNO/c1-19(2)12-13-20-17(14-6-4-3-5-7-14)15-8-10-16(18)11-9-15/h3-11,17H,12-13H2,1-2H3 YesY
  • Key:NUNIWXHYABYXKF-UHFFFAOYSA-N YesY
 NYesY (what is this?)  (verify)

Bromazine (trade names Ambrodyl, Ambrodil and others), also known as bromodiphenhydramine, is an antihistamine and anticholinergic.[1] It is a halogenated form of diphenhydramine and in many respects is somewhat stronger than the parent compound. The other three halogenated diphenhydramine derivatives are used in research and chlorodiphenhydramine is also marketed with iododiphenhydramine being a much less common pharmaceutical.

References

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