LATS1
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Serine/threonine-protein kinase LATS1 is an enzyme that in humans is encoded by the LATS1 gene.[1][2][3]
It has been associated with the Hippo signaling pathway.[4]
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.[3]
Interactions
LATS1 has been shown to interact with Zyxin[5] and Cdk1.[1]
References
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