PRKG1

Protein kinase, cGMP-dependent, type I
250px Rendering based on PDB 1ZXA.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1ZXA, 3NMD, 3OCP, 3OD0, 3OGJ, 4KU7, 4KU8, 4QX5, 4QXK
Identifiers
Symbols	PRKG1 ; AAT8; PKG; PRKG1B; PRKGR1B; cGK; cGK 1; cGK1; cGKI; cGKI-BETA; cGKI-alpha
External IDs	OMIM: 176894 MGI: 108174 HomoloGene: 55964 ChEMBL: 4273 GeneCards: PRKG1 Gene
EC number	2.7.11.12
Gene ontology Molecular function • cGMP-dependent protein kinase activity • calcium channel regulator activity • protein binding • ATP binding • cGMP binding Cellular component • cytoplasm • Golgi apparatus • cytosol • plasma membrane Biological process • neuron migration • protein phosphorylation • signal transduction • blood coagulation • dendrite development • cGMP-mediated signaling • actin cytoskeleton organization • forebrain development • regulation of GTPase activity • relaxation of vascular smooth muscle • negative regulation of platelet aggregation • activation of mitophagy in response to mitochondrial depolarization Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE PRKG1 211380 s at tn.png
File:PBB GE PRKG1 207119 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5592	19091
Ensembl	ENSG00000185532	ENSMUSG00000052920
UniProt	Q13976	P0C605
RefSeq (mRNA)	NM_001098512	NM_001013833
RefSeq (protein)	NP_001091982	NP_001013855
Location (UCSC)	Chr 10: 50.99 – 52.3 Mb	Chr 19: 30.57 – 31.77 Mb
PubMed search	[1]	[2]

cGMP-dependent protein kinase 1, alpha isozyme is an enzyme that in humans is encoded by the PRKG1 gene.

Interactions

PRKG1 has been shown to interact with:

• GTF2I,
• ITPR1,
• MRVI1,
• RGS2, and
• TNNT1.