MAPK11

Mitogen-activated protein kinase 11
250px Rendering based on PDB 3GC8.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3GC8, 3GC9, 3GP0
Identifiers
Symbols	MAPK11 ; P38B; P38BETA2; PRKM11; SAPK2; SAPK2B; p38-2; p38Beta
External IDs	OMIM: 602898 MGI: 1338024 HomoloGene: 55684 ChEMBL: 3961 GeneCards: MAPK11 Gene
EC number	2.7.11.24
Gene ontology Molecular function • protein serine/threonine kinase activity • MAP kinase activity • protein binding • ATP binding Cellular component • nucleoplasm • cytosol Biological process • activation of MAPK activity • toll-like receptor signaling pathway • MyD88-dependent toll-like receptor signaling pathway • MyD88-independent toll-like receptor signaling pathway • transcription, DNA-templated • response to stress • organelle organization • mitochondrion organization • signal transduction • Ras protein signal transduction • gene expression • positive regulation of gene expression • toll-like receptor 2 signaling pathway • toll-like receptor 3 signaling pathway • toll-like receptor 4 signaling pathway • toll-like receptor 5 signaling pathway • toll-like receptor 9 signaling pathway • toll-like receptor 10 signaling pathway • intracellular signal transduction • TRIF-dependent toll-like receptor signaling pathway • toll-like receptor TLR1:TLR2 signaling pathway • toll-like receptor TLR6:TLR2 signaling pathway • muscle cell differentiation • innate immune response • positive regulation of erythrocyte differentiation • vascular endothelial growth factor receptor signaling pathway • neurotrophin TRK receptor signaling pathway • regulation of sequence-specific DNA binding transcription factor activity • positive regulation of muscle cell differentiation • stress-activated MAPK cascade • negative regulation of cardiac muscle cell proliferation • cellular response to virus • positive regulation of interleukin-12 secretion Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE MAPK11 211499 s at tn.png
File:PBB GE MAPK11 206040 s at tn.png
File:PBB GE MAPK11 211500 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5600	19094
Ensembl	ENSG00000185386	ENSMUSG00000053137
UniProt	Q15759	Q9WUI1
RefSeq (mRNA)	NM_002751	NM_011161
RefSeq (protein)	NP_002742	NP_035291
Location (UCSC)	Chr 22: 50.26 – 50.27 Mb	Chr 15: 89.14 – 89.15 Mb
PubMed search	[1]	[2]

Mitogen-activated protein kinase 11 is an enzyme that in humans is encoded by the MAPK11 gene.

Function

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase.

Interactions

MAPK11 has been shown to interact with HDAC3 and Promyelocytic leukemia protein.

See also

• p38 mitogen-activated protein kinases

External links

• MAP Kinase Resource .