Tabalumab

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Tabalumab
Monoclonal antibody
Type Whole antibody
Source Human
Target BAFF
Identifiers
CAS Number 1143503-67-6 N
ATC code none
Chemical data
Formula C6518H10008N1724O2032S38
Molecular mass 146.25 kg/mol
 NYesY (what is this?)  (verify)

Tabalumab (LY 2127399) is an anti-B-cell activating factor (BAFF) human monoclonal antibody designed for the treatment of autoimmune diseases and B cell malignancies.[1][2] Tabalumab was developed by Eli Lilly and Company.

A phase III clinical trial for rheumatoid arthritis was halted in Feb 2013.[3] In September 2014, a second phase III trial focussing on treating systemic lupus erythematosus, was terminated early as the study failed to meet its primary endpoint.[4]

References

  1. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  2. ↑ http://www.lillyoncologypipeline.com/Pages/baff-antibody.aspx
  3. ↑ http://lilly.mediaroom.com/index.php?s=9042&item=136985
  4. ↑ http://www.genengnews.com/gen-news-highlights/lilly-halts-tabalumab-development-for-lupus/81250423/


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Now dropped by Lilly due to lack of efficacy.

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