Urocortin
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Urocortin is a protein that in humans is encoded by the UCN gene.[1][2][3]
Function
This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain, it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II.[3]
Urocortin is a potent anorexigenic peptide of 40 amino acids that induces fed-like motor activity when administered centrally or peripherally in fasted animals. Urocortin belongs to the corticotropin-releasing factor (CRF) family that includes CRF, urotensin I, sauvagine, urocortin II and urocortin III. Urocortin is also a potent and long-lasting hypotensive agent and increases coronary blood flow.
Interactions
Urocortin has been shown to interact with Corticotropin releasing hormone receptor 1.[4][5]
References
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This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it. |
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