Parathyroid hormone receptor
From Infogalactic: the planetary knowledge core
parathyroid hormone 1 receptor | |
---|---|
Identifiers | |
Symbol | PTH1R |
Alt. symbols | PTHR, PFE |
Entrez | 5745 |
HUGO | 9608 |
OMIM | 168468 |
RefSeq | NM_000316 |
UniProt | Q03431 |
Other data | |
Locus | Chr. 3 p22-p21.1 |
parathyroid hormone 2 receptor | |
---|---|
Identifiers | |
Symbol | PTH2R |
Entrez | 5746 |
HUGO | 9609 |
OMIM | 601469 |
RefSeq | NM_005048 |
UniProt | P49190 |
Other data | |
Locus | Chr. 2 q33 |
There are two known parathyroid hormone receptors in mammals termed PTH1R and PTH2R. These receptors bind parathyroid hormone and are members of the GPCR family of transmembrane proteins.[1]
- parathyroid hormone 1 receptor (PTH1R) is the classical PTH receptor, is expressed in high levels in bone and kidney and regulates calcium ion homeostasis through activation of adenylate cyclase and phospholipase C.[2][3]
- parathyroid hormone 2 receptor (PTH2R) is expressed primarily in the central nervous system, pancreas, testis, and placenta.[4]
References
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External links
- Parathyroid Hormone Receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
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