Hypocretin (orexin) receptor 1

Orexin receptor type 1 (Ox1R or OX₁), also known as hypocretin receptor type 1, is a protein that in humans is encoded by the HCRTR1 gene.

Function

The orexin 1 receptor (OX₁), is a G-protein coupled receptor that is heavily expressed in projections from the lateral hypothalamus and is involved in the regulation of feeding behaviour. OX₁ selectively binds the orexin-A neuropeptide. It shares 64% identity with OX₂.

Ligands

Agonists

• Orexin-A

Antagonists

Further information: Orexin antagonist

• RTIOX-276 - Selective OX₁ antagonist
• ACT-335827 - Selective OX₁ antagonist
• Almorexant - Dual OX₁ and OX₂ antagonist
• Lemborexant - Dual OX₁ and OX₂ antagonist
• SB-334,867 - Selective OX₁ antagonist
• SB-408,124 - Selective OX₁ antagonist
• SB-649,868 - Dual OX₁ and OX₂ antagonist
• Suvorexant - Dual OX₁ and OX₂ antagonist

See also

• Orexin receptor

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.