GPR112
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). G protein-coupled receptor 112 is a protein encoded by the ADGRG4 gene.[1][2] GPR112 is a member of the adhesion GPCR family.[3][4] Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[5]
GPR112 is expressed in human enterochromaffin cells[6] and in the mouse intestine.[7] The N-terminal fragment (NTF) of GPR112 contains pentraxin (PTX)-like modules.[7] GPR112 gene expression has been identified as a marker for neuroendocrine carcinoma cells.[6]
References
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