Retinal G protein coupled receptor

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Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). RPE-retinal G protein-coupled receptor also known as RGR-opsin is a protein that in humans is encoded by the RGR gene.[1][2]

Function

RGR-opsin is a member of the rhodopsin-like receptor subfamily of GPCR. Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain.[3][4] RGR-opsin preferentially binds all-trans-retinal,[4] which is the dominant form in the dark adapted retina,upon light exposure it is isomerized to 11-cis-retinal.[5] Therefore, RGR-opsin presumably acts as a photoisomerase to convert all-trans-retinal to 11-cis-retinal, similar to retinochrome in invertebrates. 11-cis-retinal is isomerized back within rhodopsin and the iodopsins in the rods and cones of the retina. RGR-opsin is exclusively expressed in tissue close to the rods and cones, the retinal pigment epithelium (RPE) and Müller cells.[3] RGR-opsin may be associated with autosomal recessive and autosomal dominant retinitis pigmentosa (arRP and adRP, respectively). RGR-opsin comes in different isoforms produced by alternative splicing.[2]

Interactions

RGR-opsin has been shown to interact with KIAA1279.[6]

References

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  2. ↑ 2.0 2.1 Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ 3.0 3.1 Lua error in package.lua at line 80: module 'strict' not found.
  4. ↑ 4.0 4.1 Lua error in package.lua at line 80: module 'strict' not found.
  5. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  6. ↑ Lua error in package.lua at line 80: module 'strict' not found.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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