Calcitonin receptor

Calcitonin receptor
Identifiers
Symbols	CALCR ; CRT; CT-R; CTR; CTR1
External IDs	OMIM: 114131 MGI: 101950 HomoloGene: 1320 IUPHAR: 43 ChEMBL: 1832 GeneCards: CALCR Gene
Gene ontology Molecular function • receptor activity • calcitonin receptor activity • protein binding • protein transporter activity • calcitonin binding Cellular component • cytosol • plasma membrane • integral component of plasma membrane Biological process • cell surface receptor signaling pathway • G-protein coupled receptor signaling pathway • adenylate cyclase-activating G-protein coupled receptor signaling pathway • activation of adenylate cyclase activity • activation of phospholipase C activity • positive regulation of cytosolic calcium ion concentration • protein transport • positive regulation of cAMP biosynthetic process • receptor internalization • positive regulation of adenylate cyclase activity • response to glucocorticoid • protein localization to plasma membrane Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	799	12311
Ensembl	ENSG00000004948	ENSMUSG00000023964
UniProt	P30988	Q60755
RefSeq (mRNA)	NM_001164737	NM_001042725
RefSeq (protein)	NP_001158209	NP_001036190
Location (UCSC)	Chr 7: 93.42 – 93.57 Mb	Chr 6: 3.69 – 3.76 Mb
PubMed search	[1]	[2]

The calcitonin receptor (CT) is a G protein-coupled receptor that binds the peptide hormone calcitonin and is involved in maintenance of calcium homeostasis, particularly with respect to bone formation and metabolism.

CT works by activating the G-proteins G_s and G_q often found on osteoclasts, on cells in the kidney, and on cells in a number of regions of the brain. It may also affect the ovaries in women and the testes in men.

The function of the CT receptor protein is modified through its interaction with Receptor activity-modifying proteins (RAMPs), forming the multimeric amylin receptors AMY₁ (CT + RAMP1), AMY₂ (CT + RAMP2), and AMY₃ (CT+ RAMP3).

Interactions

Calcitonin receptor has been shown to interact with Apolipoprotein B and LRP1.

External links

• Calcitonin receptors at the US National Library of Medicine Medical Subject Headings (MeSH)