KCNN4
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4, also known as KCNN4, is a human gene encoding the KCa3.1 protein.[1]
Function
The KCa3.1 protein is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane depolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.[1]
History
The channel activity was first described in 1958 by Gyorgi Gardos in human erythrocytes.[2] The channels is also named Gardos channel because of its discoverer.
See also
References
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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