Nav1.9

Sodium channel, voltage-gated, type XI, alpha subunit
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1byy
Identifiers
Symbols	SCN11A ; NAV1.9; NaN; SCN12A; SNS-2
External IDs	OMIM: 604385 MGI: 1345149 HomoloGene: 8041 IUPHAR: 586 ChEMBL: 5167 GeneCards: SCN11A Gene
Gene ontology Molecular function • voltage-gated sodium channel activity Cellular component • voltage-gated sodium channel complex • C-fiber Biological process • sodium ion transport • response to drug Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	11280	24046
Ensembl	ENSG00000168356	ENSMUSG00000034115
UniProt	Q9UI33	Q9R053
RefSeq (mRNA)	NM_014139	NM_011887
RefSeq (protein)	NP_054858	NP_036017
Location (UCSC)	Chr 3: 38.89 – 38.99 Mb	Chr 9: 119.75 – 119.83 Mb
PubMed search	[1]	[2]

Sodium channel, voltage-gated, type XI, alpha subunit also known as SCN11A or Na_v1.9 is a voltage-gated sodium ion channel protein which in humans is encoded by the SCN11A gene.

Function

Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the action potential in most excitable cells. Alpha subunits, such as SCN11A, mediate voltage-dependent gating and conductance, while auxiliary beta subunits regulate the kinetic properties of the channel and facilitate membrane localization of the complex. Aberrant expression patterns or mutations of alpha subunits underlie a number of disorders. Each alpha subunit consists of 4 domains connected by 3 intracellular loops; each domain consists of 6 transmembrane segments and intra- and extracellular linkers.

Clinical significance

Mutations in this gene have been associated to loss of pain perception.

External links

• SCN11A protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.