TRPV5

Transient receptor potential cation channel, subfamily V, member 5
Identifiers
Symbols	TRPV5 ; CAT2; ECAC1; OTRPC3
External IDs	OMIM: 606679 MGI: 2429764 HomoloGene: 10520 IUPHAR: 511 ChEMBL: 1628474 GeneCards: TRPV5 Gene
Gene ontology Molecular function • calcium channel activity • protein binding • calmodulin binding Cellular component • plasma membrane • integral component of plasma membrane • apical plasma membrane Biological process • calcium ion transport • ion transmembrane transport • protein tetramerization • transmembrane transport • calcium ion transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	56302	194352
Ensembl	ENSG00000127412	ENSMUSG00000036899
UniProt	Q9NQA5	P69744
RefSeq (mRNA)	NM_019841	NM_001007572
RefSeq (protein)	NP_062815	NP_001007573
Location (UCSC)	Chr 7: 142.91 – 142.93 Mb	Chr 6: 41.65 – 41.68 Mb
PubMed search	[1]	[2]

Transient receptor potential cation channel subfamily V member 5 is a protein that in humans is encoded by the TRPV5 gene.

TRPV5 is mainly expressed in kidney epithelial cells, where it plays an important role in the reabsorption of Ca²⁺. Genetic deletion of TRPV5 in mice leads to Ca²⁺ loss in the urine, and consequentual hyperparathyroidism, and bone loss.

Function

This gene is a member of the transient receptor family and the TRPV subfamily. The calcium-selective channel , TRPV5, encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level.

Interactions

TRPV5 has been shown to interact with S100A10.

See also

• TRPV

External links

• TRPV5 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.