Receptor activity-modifying protein
| Receptor activity-modifying protein 1 | |
|---|---|
| Identifiers | |
| Symbol | RAMP1 |
| Entrez | 10267 |
| HUGO | 9843 |
| OMIM | 605153 |
| RefSeq | NM_005855 |
| UniProt | O60894 |
| Other data | |
| Locus | Chr. 2 q36-37.1 |
| Receptor activity-modifying protein 2 | |
|---|---|
| Identifiers | |
| Symbol | RAMP2 |
| Entrez | 10266 |
| HUGO | 9844 |
| OMIM | 605154 |
| RefSeq | NM_005854 |
| UniProt | O60895 |
| Other data | |
| Locus | Chr. 17 q12-21.1 |
| Receptor activity-modifying protein 3 | |
|---|---|
| Identifiers | |
| Symbol | RAMP3 |
| Entrez | 10268 |
| HUGO | 9845 |
| OMIM | 605155 |
| RefSeq | NM_005856 |
| UniProt | O60896 |
| Other data | |
| Locus | Chr. 7 q13-p12 |
Receptor activity-modifying proteins (RAMPs) are a class of protein that interact with and modulate the activities of several Class B G Protein-Coupled Receptors including the receptors for secretin, calcitonin (CT), glucagon, and vasoactive intestinal peptide (VIP).[1] There are three distinct types of RAMPs, designated RAMP1, RAMP2, and RAMP3, each encoded by a separate gene.[2]
Contents
Function
Currently, the function of RAMPs is divided into classes activities. When associated with the Calcitonin receptor (CTR) or Calcitonin receptor-like (CALCRL) (below), RAMPs can change the selectivity of the receptor for a specific hormone. In the cases of the other receptors mentioned, however, there is no evidence that they can do this, but instead function to regulate trafficking of receptors from the ER / golgi to the membrane. These functions appear to be ones where there is redundancy, as neither RAMP1 nor RAMP3 knockout mice (KO) have grossly abnormal phenotypes. The likelihood is that the phenotype of RAMP2 KO mice is more connected with the abolition of most adrenomedullin (AM) signalling than effects on trafficking of other receptors, as those mice are almost identical to AM KO mice.
Types
Association of RAMPs with either the CT or CALCRL proteins forms 6 different receptors from the calcitonin receptor family:[3][4][5]
| GPCR | RAMP isoform | resultant receptor |
|---|---|---|
| Calcitonin receptor-like | RAMP1 | CGRP |
| RAMP2 | adrenomedullin (AM) receptor, designated AM1[6] | |
| RAMP3 | dual CGRP/AM receptor, designated AM2 | |
| Calcitonin receptor | RAMP1 | amylin receptor AMY1 |
| RAMP2 | amylin receptor AMY2 | |
| RAMP3 | amylin receptor AMY3 |
References
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External links
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- Receptor activity modifying protein at the US National Library of Medicine Medical Subject Headings (MeSH)
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