KLRC2
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). NKG2-C type II integral membrane protein is a protein that in humans is encoded by the KLRC2 gene.[1][2]
Function
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined.[2]
Interactions
KLRC2 has been shown to interact with KLRD1.[3][4] The binding of this CD94/NKG2C heterodimer to its cellular ligand HLA-E has been shown to drive the expansion of a subset of Natural Killer (NK) cells in response to viral infections.[5]
See also
References
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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