Transferrin receptor 1
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Transferrin receptor protein 1 (TfR1), also known as Cluster of Differentiation 71 (CD71), is a protein that in humans is encoded by the TFRC gene.[1][2] TfR1 is required for iron import from transferrin into cells by endocytosis.[3][4]
Structure and function
TfR1 is a transmembrane glycoprotein composed of two disulfide-linked monomers joined by two disulfide bonds. Each monomer binds one holo-transferrin molecule creating an iron-Tf-TfR complex which enters the cell by endocytosis.[5]
Clinical significance
TfR1 as a potential new target in cases of human leukemia & lymphoma. InatherYs, in Évry, France, developed a candidate drug, INA01 antibody (anti-CD71) that showed efficacy in pre-clinical studies in the therapy of two incurable orphan oncohematological diseases: the adult T cell leukemia (ATLL) caused by HTLV-1 and the Mantle cell lymphoma (MCL).[citation needed]
Interactions
TfR1 has been shown to interact with GABARAP[6] and HFE.[7][8]
See also
References
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